PLINEST® HAIR (1 x 2ml), PN-HPT™ Scalp & Hair Follicle Regeneration
Clinically proven hair loss treatment. Trophic scalp stimulation backed by real-world data.
Hair thinning and scalp deterioration affect a significant proportion of both male and female patients, yet injectable treatment options for the scalp remain far less developed than those for facial skin. PLINEST® HAIR is Mastelli’s dedicated scalp formulation, a PN-HPT™ based injectable specifically developed and clinically validated for trophic stimulation of the scalp to promote hair growth, with proven results in female hormonal hair loss and broad application across the most common causes of hair thinning.
Unlike topical hair treatments that act on the surface, PLINEST® HAIR works intradermally, delivering polynucleotides directly to the scalp tissue where hair follicles live, improving their biological environment from within.
Clinical Evidence
Plinest Hair’s efficacy is supported by a published clinical study in patients with female hormonal alopecia:
20 female patients aged 25–65 with non-androgen-dependent female hormonal alopecia
Video dermoscopy demonstrated a measurable increase in average hair count, from 105 hair/cm² at baseline (T0) to 118 hair/cm² after treatment (T12)
Trichogram values improved, with an increase in hair in anagen (growing phase) and a reduction in telogen (resting phase), indicating a genuine shift in follicular biology, not just surface improvement
No side effects reported, the product was very well tolerated throughout the treatment course
What PLINEST® HAIR Treats
PLINEST® HAIR is indicated for trophic action on hair and eyebrows, with clinical application across:
Androgenetic alopecia, male and female pattern hair loss at early and intermediate stages
Telogen effluvium, stress-induced, post-pregnancy, post-infection, or seasonal hair shedding
Diffuse or reactive hair loss, generalised thinning without a clearly defined pattern
Fine, weakened, or dull hair, loss of hair density, thickness, and vitality
Devitalised scalp, poor scalp condition affecting follicular health and hair growth
Eyebrow thinning, trophic stimulation for sparse or weakened brow hair
Maintenance and prevention, used in patients at risk of progressive hair loss to slow deterioration and maintain density
Mechanism of Action
Injected intradermally into the scalp, PN-HPT™ targets the biological environment of the hair follicle:
Follicle stimulation, activates fibroblasts and the extracellular matrix surrounding the hair follicle, improving follicular function and vitality
Scalp microcirculation, enhances local blood flow, increasing oxygen and nutrient delivery to follicle cells and supporting the transition from telogen to anagen phase
Anti-inflammatory action, reduces scalp inflammation, a key driver of follicular miniaturisation in both androgenetic and reactive alopecia
Enhanced protein synthesis, supports keratinocyte activity and the structural proteins needed for healthy hair shaft production
Scalp hydration, improves the hydration status of scalp tissue, creating a more favourable environment for follicle regeneration
Administration Protocol
Plinest Hair follows a two-phase protocol for optimal results:
Phase Frequency Sessions
Phase I (Induction) Every 7 or 14 days 4 sessions
Phase II (Consolidation) Every 21–30 days 4 further sessions
Parameter Detail
Injection technique Micro-droplet or linear retrograde
Injection depth Intradermal
Volume per session 2ml
Needle gauge 30G ½” (2 x 30G ½” needles included)
Areas Scalp and eyebrows
Session duration 30–45 minutes
Downtime Minimal
Key Product Details
Specification Detail
Active Ingredient PN-HPT™ (Polynucleotides Highly Purified Technology)
Concentration 15mg/2ml
Volume 2ml prefilled syringe
Pack Contents 1 x 2ml syringe + 2 x 30G ½” needles
Treatment Areas Scalp and eyebrows
Manufacturer Mastelli Srl, Italy
Certification CE-marked medical device
⚠️ For use by qualified and trained aesthetic practitioners only.
Why Practitioners Choose PLINEST® HAIR
✅ Clinically proven results, published data showing measurable increase in hair count and shift from telogen to anagen phase
✅ Dedicated scalp formulation, not a repurposed facial booster; developed and validated specifically for trophic stimulation of the scalp and follicle environment
✅ Broad indication range, effective across androgenetic alopecia, telogen effluvium, diffuse hair loss, and scalp deterioration
✅ Eyebrow rejuvenation, indicated for eyebrow thinning as well as scalp use, extending treatment options in a single product
✅ Excellent synergy, PN-HPT™ Priming enhances the effects of complementary treatments including biotin, hyaluronic acid, carboxytherapy, and topical therapy
✅ Outstanding tolerability, no side effects reported in published clinical study; very well tolerated across all patients
✅ Hormone-free and biocompatible, no hormonal additives; suitable for both male and female patients including post-pregnancy hair loss
Important Safety Information
Contraindicated in patients with known allergy to fish or fish products, active scalp infection or inflammation at the injection site, bleeding disorders, autoimmune conditions, or who are pregnant or breastfeeding. Common side effects include transient redness, mild tenderness, and pinpoint bruising at injection sites, typically resolving within hours.
Order PLINEST® HAIR (1x2ml) at AlphaBotox with free shipping on orders over €350. New customer? Get 15% off your first order, automatically applied at checkout.
