MACROLANE™ VRF 30 (1 x 10ml), NASHA™ Hyaluronic Acid Body Filler
The gold standard in non-surgical body volume restoration. Precise. Biodegradable. Long-lasting.
Macrolane™ VRF 30 is a premium large-volume hyaluronic acid body filler developed by Q-Med, part of Galderma, the world leader in dermatology and aesthetic medicine. Built on the same proven NASHA™ (Non-Animal Stabilised Hyaluronic Acid) technology that underpins the Restylane® family, Macrolane is specifically engineered for body use, delivering the viscosity, cohesivity, and volume capacity that facial fillers simply cannot provide.
The “VRF” in its name stands for Volume Restoration Factor, reflecting its core purpose: restoring, reshaping, and recontouring body areas where volume has been lost, reduced, or is naturally deficient. The 10ml syringe format makes it particularly suited to larger treatment areas requiring meaningful volumetric change in a single session.
What Is Macrolane VRF 30 Used For?
Macrolane VRF 30 is indicated for non-surgical body contouring and volume restoration, including:
Buttock contouring and enhancement, non-surgical augmentation and reshaping without the risks associated with permanent implants
Calf sculpting, restoring volume and shape to the lower legs for a more balanced, proportionate appearance
Scar correction, filling depressed or dent-shaped scars, including those resulting from liposuction or injury
Post-liposuction irregularities, correcting contour deformities and volume defects following surgical procedures
General body contouring, addressing asymmetries and volume loss in subcutaneous tissue
Note on breast use: Q-Med discontinued the breast augmentation indication for Macrolane following guidance from radiological bodies regarding potential interference with mammography. Macrolane VRF 30 is not indicated or recommended for breast tissue augmentation.
VRF 30 vs VRF 20, Which to Use?
Macrolane is available in two formulations, VRF 20 and VRF 30, which can be used independently or in combination:
Macrolane VRF 20 Macrolane VRF 30
Viscosity Lower Higher
Best for Superficial irregularities, fine contouring, surface smoothing Deep tissue volume, significant augmentation
Injection plane Superficial subcutaneous Deep subcutaneous, above muscle
Typical use Finishing layer, post-lipo correction Primary volume restoration
In practice, many practitioners use VRF 20 as a superficial finishing layer and VRF 30 as the deep volume base, combining both for optimal natural-looking results.
How Macrolane VRF 30 Works
Macrolane utilises NASHA™ technology to produce a highly cross-linked, stable hyaluronic acid gel that integrates with surrounding subcutaneous tissue without migration. Unlike standard facial fillers, it is formulated to withstand the mechanical forces exerted in larger body areas while maintaining its shape and volume over time.
The procedure typically involves:
Assessment, evaluation of treatment areas in static and dynamic positions; patient goals discussed
Preparation, local anaesthetic applied; a small 2–3mm incision made at the access point
Injection, VRF 30 is introduced via a large-gauge spinal needle or cannula, deep into the subcutaneous layer above the muscle
Moulding, the practitioner shapes the gel externally to achieve the desired contour
Recovery, no general anaesthetic required; most patients resume normal activity within days
Treatment duration is approximately 30–45 minutes depending on the areas treated and volume used.
Key Product Details
Specification Detail
Active Ingredient Stabilised Hyaluronic Acid (NASHA™)
Volume 10ml per syringe
Formulation Non-animal origin; biodegradable
Injection Plane Deep subcutaneous (above muscle)
Duration of Effect Up to 12–18 months
Manufacturer Q-Med / Galderma
Animal Derivatives None
Retreatment As required; product is fully biodegradable
⚠️ For use by qualified and specifically trained medical practitioners only. Macrolane must not be used on the face. Injection into the wrong plane may result in product visibility or adverse outcomes. Always refer to full product guidelines before use.
Why Practitioners Choose Macrolane VRF 30
✅ Proven NASHA™ technology, the same trusted platform as the Restylane® family, adapted for larger body volumes with enhanced viscosity and cohesivity
✅ No migration, the high degree of cross-linking ensures the gel remains in place at the injection site
✅ Biodegradable and reversible, naturally broken down by the body over time; can be dissolved with hyaluronidase if required
✅ No animal derivatives, pure, synthetic HA with no risk of animal-origin contamination
✅ Minimal downtime, patients typically return to daily activities within 24–48 hours
✅ Natural-looking results, the 10ml volume and high viscosity allow for meaningful augmentation without an artificial appearance
✅ Flexible use, can be used alone or in combination with VRF 20 for layered, precision contouring
Important Safety Information
Macrolane VRF 30 is contraindicated in patients who:
Have known hypersensitivity to hyaluronic acid or any excipients
Have an autoimmune disease
Have an active infection or skin condition at the proposed treatment site
Are pregnant or breastfeeding
Common side effects include temporary swelling, bruising, tenderness, and mild discomfort at the injection site, all typically resolving within days. A prophylactic course of antibiotics may be prescribed pre- and post-treatment at the practitioner’s discretion.
Macrolane must not be injected into the face, blood vessels, muscles, tendons, ligaments, or bone.
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