PLINEST® FAST (1 x 2ml), PN-HPT™ Polynucleotide Skin Booster
Rapid regeneration. Deep cellular repair. Visible results from the first session.
PLINEST® Fast is an advanced injectable polynucleotide (PN) skin booster from Mastelli, one of Italy’s most respected names in regenerative aesthetics, formulated specifically for patients who need accelerated skin recovery, intensive biostimulation, or rapid improvement in skin quality. It is the fast-acting evolution of the established PLINEST® range, engineered with low molecular weight PN-HPT™ (Polynucleotides Highly Purified Technology) for quicker absorption, faster onset of biological response, and a gentler injection experience.
Where standard skin boosters primarily replenish surface hydration, PLINEST® Fast works at a cellular level, activating the skin’s own regenerative mechanisms to rebuild structure, resilience, and radiance from within.
What Makes PLINEST® Fast Different?
The key differentiator is the PN-HPT™ formulation, Mastelli’s proprietary polynucleotide technology. Unlike standard PDRN or PN products, PN-HPT™ polynucleotides are:
Highly purified, removing immunogenic and inflammatory components that can cause reactions
Low molecular weight, allowing faster absorption into the dermis and a quicker onset of cellular activity
Salmon/trout-derived, naturally biocompatible with human tissue due to high DNA sequence homology
This combination produces faster biostimulation than conventional polynucleotide formulations, making PLINEST® Fast the product of choice when speed of result matters, post-procedure recovery, skin in acute distress, or patients with minimal time between sessions.
Mechanism of Action
Once injected into the superficial dermis, PLINEST® Fast initiates three key biological pathways:
1. Fibroblast Activation
PN-HPT™ directly stimulates fibroblasts, the cells responsible for synthesising collagen type I & III and elastin. Clinical data shows polynucleotides increase collagen I & III production by up to 60% and elastin by 35%, visibly improving skin firmness and elasticity.
2. Enhanced Microcirculation
The formula improves local microvascular activity, accelerating the delivery of oxygen and nutrients to skin cells while clearing metabolic waste. This supports faster cell turnover and a more radiant complexion.
3. Antioxidant Protection
PN-HPT™ neutralises free radicals and reduces oxidative stress, one of the primary drivers of premature skin ageing. By protecting cellular DNA and membrane integrity, it prolongs the health and vitality of treated tissue.
Clinical Indications
PLINEST® Fast is indicated for:
Tired, dehydrated, or damaged skin, restoring hydration, luminosity, and skin turgidity
Fine lines and superficial wrinkles, particularly periorbital lines, neck, and décolletage
Post-procedure recovery, accelerating tissue repair after laser resurfacing, chemical peels, microneedling, or other energy-based treatments
Early-stage photoaging, reversing sun damage and restoring barrier function
Acne scarring and enlarged pores, improving skin texture and tone through collagen remodelling
Scalp and hair rejuvenation, stimulating follicle health and microcirculation in cases of mild alopecia or scalp dehydration
Loss of elasticity and skin tone, in the face, neck, décolletage, hands, and inner arms
Treatment Areas
Area Suitability
Face (full) ✅ Ideal
Periorbital region ✅ Ideal, low molecular weight ensures safe use in delicate zones
Neck ✅ Ideal
Décolletage ✅ Ideal
Hands ✅ Suitable
Scalp ✅ Suitable, for hair and follicle rejuvenation
Administration Protocol
Parameter Detail
Injection technique Superficial microinjections, intradermal / papular
Needle gauge 30G–33G (2 x 30G ½” needles included)
Session frequency 2–4 sessions spaced 2 weeks apart
Maintenance Every 2–3 months to sustain results
Session duration Approximately 30–45 minutes
Downtime Minimal, mild redness/swelling typically resolves within hours
Key Product Details
Specification Detail
Active Ingredient Polynucleotides PN-HPT™ (salmon/trout-derived)
Concentration 15mg per syringe (7.5mg/ml)
Volume 2ml prefilled syringe
Pack Contents 1 x 2ml syringe + 2 x 30G ½” needles
Manufacturer Mastelli Srl, Italy
Certification CE-marked medical device
Results Duration 4–6 months (maintenance recommended every 2–3 months)
Origin Highly purified salmon/trout polynucleotides
⚠️ For use by qualified and trained aesthetic practitioners only.
Why Practitioners Choose PLINEST® Fast
✅ Faster onset than standard PN formulations, low molecular weight PN-HPT™ absorbs more rapidly, delivering quicker visible improvement
✅ Proven collagen stimulation, up to 60% increase in collagen I & III and 35% increase in elastin, backed by clinical data
✅ Safe in delicate zones, suitable for periorbital, neck, and décolletage areas where other biostimulators may be too heavy
✅ Ideal post-procedure companion, accelerates healing after laser, peeling, or injectables, reducing downtime and improving final outcomes
✅ Excellent compatibility, works synergistically with microneedling, radiofrequency, dermal fillers, and other aesthetic procedures
✅ Minimal side effects, highly purified formulation dramatically reduces inflammatory response compared to less refined PN products
✅ Versatile, addresses face, neck, décolletage, scalp, and hands in a single product
Important Safety Information
PLINEST® Fast is contraindicated in patients who:
Have a known allergy to fish or fish products (polynucleotides are salmon/trout-derived)
Have bleeding disorders or are on anticoagulant therapy
Have autoimmune conditions affecting skin healing
Have an active skin infection or inflammation at the proposed injection site
Are pregnant or breastfeeding (insufficient safety data available)
Common side effects include transient redness, mild swelling, and pinpoint bruising at injection sites, typically resolving within a few hours. These are consistent with the nature of superficial microinjections.
Order PLINEST® Fast (1 x 2ml) at AlphaBotox with free shipping on orders over €350. New customer? Get 15% off your first order, automatically applied at checkout.
