PLINEST® (1 x 2ml), PN-HPT™ Polynucleotide Skin Booster
PLINEST® polynucleotide is the original and best-established product in Mastelli’s PN-HPT™ range, a clinically proven injectable polynucleotide skin booster that works progressively to rebuild skin quality, restore elasticity, and stimulate the body’s own collagen and elastin production from within. Where Plinest Fast is optimised for speed and acute recovery, standard Plinest is the treatment of choice for ongoing skin health, delivering deeper, more sustained regenerative results through a structured course of sessions.
Built on Mastelli’s proprietary PN-HPT™ (Polynucleotides Highly Purified Technology), PLINEST® contains highly purified salmon-derived polynucleotides at a higher concentration (20mg/ml) than Plinest Fast, making it the stronger, more regeneratively potent formulation, engineered for patients seeking meaningful, long-lasting improvement in skin structure, firmness, and tone.
Plinest vs Plinest Fast, Choosing the Right Formulation
PLINEST® polynucleotide PLINEST® Fast
PN concentration 20mg/ml (higher) 7.5mg/ml (lower)
Molecular weight Standard Low, faster absorption
Primary role Progressive regeneration, long-term skin quality Rapid biostimulation, post-procedure recovery
Best for Ageing, damaged, or collagen-depleted skin Sensitive areas, acute skin stress, fast onset
Ideal patient Patients on a structured rejuvenation programme Patients needing fast results or post-treatment support
Can be combined ✅ Yes, with Plinest Fast, fillers, microneedling ✅ Yes, with Plinest, energy-based treatments
For practitioners running structured skin programmes, PLINEST® is typically the foundation treatment, delivering the deeper regenerative stimulus, with Plinest Fast used as a rapid-onset companion for delicate zones or post-procedure sessions.
Mechanism of Action
Once injected intradermally, PLINEST® PN-HPT™ activates three core biological pathways:
1. Fibroblast Activation & Collagen Induction
PN-HPT™ stimulates fibroblasts to produce collagen type I & III and elastin, the structural proteins responsible for skin firmness, resilience, and elasticity. Clinical data shows PLINEST® increases collagen I & III by up to 60% and elastin by 35%, producing visible improvements in skin density and tightness over the course of treatment.
2. Enhanced Microcirculation
The formula improves local blood flow, accelerating oxygen and nutrient delivery to skin cells while supporting efficient clearance of metabolic waste. The result is a more radiant, healthy-looking complexion with improved skin turgidity.
3. Antioxidant Protection
PN-HPT™ neutralises free radicals, reducing oxidative stress and protecting cellular DNA integrity. This slows the degradation of existing collagen and extends the longevity of newly synthesised tissue.
Clinical Indications
PLINEST® polynucleotide is indicated for the prevention and correction of skin ageing signs and the improvement of skin quality across multiple dimensions, including:
Photoageing and sun damage, reversing UV-induced collagen loss and restoring barrier function
Loss of elasticity and skin tone, rebuilding structural collagen to restore firmness and tightness
Dehydration and dull skin, improving skin turgidity, luminosity, and overall hydration status
Fine lines and superficial wrinkles, particularly periorbital lines, neck lines, and perioral wrinkles
Acne scarring and enlarged pores, remodelling collagen to improve surface texture and refine pores
Skin in need of structural regeneration, patients with significant collagen loss due to ageing, lifestyle, or environmental damage
Preventive anti-ageing, used in younger patients to maintain skin quality and delay the onset of visible ageing
Treatment Areas
Area Suitability
Full face ✅ Ideal
Neck ✅ Ideal
Décolletage ✅ Ideal
Hands ✅ Suitable
Periorbital region ✅ Suitable (note: Plinest Fast preferred for very delicate periorbital use)
Scalp ✅ Suitable for follicle and scalp rejuvenation
Administration Protocol
Parameter Detail
Injection technique Superficial microinjections, intradermal / papular
Needle gauge 30G–33G (2 x 30G ½” needles included)
Session frequency 3–4 sessions spaced 2 weeks apart
Maintenance Every 2–3 months to sustain results
Session duration Approximately 30–45 minutes
Downtime Minimal, mild redness/swelling resolves within hours
The higher PN concentration of standard Plinest polynucleotide relative to Plinest Fast means it is particularly well suited to patients with more established signs of ageing or collagen loss who will benefit from a stronger regenerative stimulus across the treatment course.
Key Product Details
Specification Detail
Active Ingredient Polynucleotides PN-HPT™ (salmon-derived)
Concentration 20mg/ml (40mg per syringe)
Volume 2ml prefilled syringe
Pack Contents 1 x 2ml syringe + 2 x 30G ½” needles
Manufacturer Mastelli Srl, Italy
Certification CE-marked medical device
Results Duration 4–6 months (maintenance every 2–3 months)
Origin Highly purified salmon polynucleotides
⚠️ For use by qualified and trained aesthetic practitioners only.
Why Practitioners Choose PLINEST® polynucleotide
✅ Higher PN concentration than Plinest Fast, 20mg/ml vs 7.5mg/ml, delivering a stronger regenerative stimulus per session
✅ Clinically proven collagen induction, up to 60% increase in collagen I & III and 35% increase in elastin, backed by published clinical data
✅ Progressive, long-lasting results, structured course of 3–4 sessions builds cumulative improvements in skin density and texture
✅ Ideal for established ageing, the stronger formulation makes it the go-to for patients with meaningful collagen loss, photoageing, or skin laxity
✅ Excellent combination treatment, pairs seamlessly with Plinest Fast, dermal fillers, microneedling, radiofrequency, and laser for comprehensive skin programmes
✅ Highly purified, minimal side effects, PN-HPT™ technology removes immunogenic components, delivering superior tolerability versus less refined PN products
✅ Hormone-free and biocompatible, no hormonal additives; naturally biodegradable and well tolerated across all skin types
Important Safety Information
PLINEST® polynucleotide is contraindicated in patients who:
Have a known allergy to fish or fish products (polynucleotides are salmon-derived)
Have bleeding disorders or are on anticoagulant therapy
Have autoimmune conditions affecting skin healing
Have an active skin infection or inflammation at the proposed injection site
Are pregnant or breastfeeding
Common side effects include transient redness, mild swelling, and pinpoint bruising at injection sites, typically resolving within a few hours. Avoid intense sun exposure, strenuous exercise, sauna, and steam baths for at least 24 hours post-treatment.
Order PLINEST® (1x2ml) at AlphaBotox with free shipping on orders over €350. New customer? Get 15% off your first order, automatically applied at checkout.
