NUCLEOFILL™ MEDIUM

NUCLEOFILL™ MEDIUM Product Summary
NUCLEOFILL™ MEDIUM is a bio-restructuring injectable gel formulated with natural polynucleotides. It is specifically designed to provide hydration, anti-aging benefits, and skin rejuvenation for mild to moderate signs of aging. The product offers biostimulation at the dermal level, enhancing skin quality and elasticity.

Formulation: Polynucleotide-based gel with high viscosity.
Packaging: Pre-filled syringe (1.5 mL) with 30G needles included.
pH: 6.8–7.2 for physiological compatibility.

NUCLEOFILL™ MEDIUM Key Features and Benefits
NUCLEOFILL™ MEDIUM provides a holistic approach to skin rejuvenation by addressing hydration, antioxidant protection, and fibroblast stimulation.

Hydration: Retains water molecules, offering deep and long-lasting hydration.
Antioxidant Protection: Neutralizes free radicals, reducing oxidative stress at the cellular level.
Fibroblast Activation: Stimulates collagen Type I production, improving skin texture and elasticity.
Bio-Lifting Effect: Provides a subtle lifting effect through myofibroblast activation.
Skin Renewal: Promotes autologous tissue regeneration for a healthier dermal matrix.

NUCLEOFILL™ MEDIUM Composition
The advanced formulation ensures effective hydration and anti-aging action.

Polynucleotide Concentration: 2%.
Molecular Weight: 2,500 kDa for optimal dermal bioavailability.
Viscosity: 28–43 Pa*s, allowing precise application and integration into tissues.

NUCLEOFILL™ MEDIUM Intended Purpose / Indications
This product is ideal for the prevention and treatment of early signs of aging and skin damage.

Primary Indications:

Hydration and bio-restructuring of the dermis.
Prevention of mild wrinkles and fine lines.
Treatment of small atrophic scars, such as acne scars.

Targeted Areas: Recommended for the face, neck, décolleté, and hands.

NUCLEOFILL™ MEDIUM Injection and Treatment Areas
NUCLEOFILL™ MEDIUM is suitable for various treatment zones to achieve optimal biorestructuring.

Injection Areas:

Face: Cheeks, nasolabial folds, and under-eye area.
Neck and décolleté: To improve elasticity and hydration.
Hands: For skin rejuvenation and reduction of fine lines.

Injection Depth: Dermis or subcutaneous layer, depending on the treatment goals.

NUCLEOFILL™ MEDIUM Reconstitution and Preparation Guidelines
The product is pre-filled and ready for immediate use without requiring additional preparation.

Preparation Steps:

Open the sterile packaging under aseptic conditions.
Attach the included 30G needle securely to the syringe.
Expel any air bubbles before beginning the injection.

NUCLEOFILL™ MEDIUM Administration and Dosage
Proper administration techniques ensure effective results and patient safety.

Injection Techniques:

Utilize a multi-puncture or linear threading technique.
Apply 0.1 mL per injection point at a spacing of 1 cm.

Dosage:

Administer 1.5 mL per session, with adjustments based on the treatment area.

NUCLEOFILL™ MEDIUM Storage Instructions
Correct storage practices maintain product quality and efficacy.

Store between 2–30°C in a dry, cool environment.
Protect from direct sunlight and freezing temperatures.
Ensure use before the expiration date printed on the packaging.

NUCLEOFILL™ MEDIUM Contraindications
The product should not be used in specific cases to avoid complications.

Do Not Use:

In patients allergic to polynucleotides or any component of the formulation.
On areas with active infections, inflammation, or lesions.
In pregnant or breastfeeding individuals.
In patients with autoimmune disorders or severe chronic illnesses.

NUCLEOFILL™ MEDIUM Precautions and Warnings
Adherence to safety guidelines ensures successful treatment outcomes.

Avoid injecting into vascular areas to prevent intravascular complications.
Do not combine with other fillers or aesthetic procedures in the same session.
Ensure thorough patient consultation regarding medical history and allergies.

NUCLEOFILL™ MEDIUM Post-Treatment Care
Following post-treatment guidelines maximizes results and reduces recovery time.

Recommendations:

Avoid makeup and skincare products for 12 hours post-procedure.
Protect the treated area from UV exposure and extreme temperatures for 48 hours.
Use a gentle moisturizer and SPF 50 sunscreen daily.

NUCLEOFILL™ MEDIUM Side Effects and Adverse Reactions
NUCLEOFILL™ MEDIUM is generally well-tolerated, with mild and temporary side effects.

Common Side Effects:

Redness, swelling, or bruising at the injection site.
Temporary tenderness or itching.

Rare Reactions:

Hypersensitivity or granuloma formation.

NUCLEOFILL™ MEDIUM Patient Eligibility
This product is suitable for adults seeking minimally invasive rejuvenation.

Ideal Candidates:

Individuals with mild to moderate skin aging signs.
Patients with dehydrated or stressed skin.

Not recommended for individuals under 18 years or with unrealistic expectations.

NUCLEOFILL™ MEDIUM Follow-Up and Maintenance
Regular treatments sustain results and improve long-term skin quality.

Treatment Protocol:

Initial sessions: Three treatments spaced 2–3 weeks apart.
Maintenance: One session every 4–6 months.

NUCLEOFILL™ MEDIUM Manufacturer and Regulatory Information
NUCLEOFILL™ MEDIUM is manufactured under stringent safety and quality standards.

Manufacturer: Biosimil Aesthetics.
Certifications: CE-marked for safety and efficacy.