NUCLEOFILL™ MEDIUM PLUS

NUCLEOFILL MEDIUM PLUS Product Summary
Nucleofill is the new line of natural polynucleotide-based bio stimulating gels designed for skin revitalization and repair. NUCLEOFILL MEDIUM PLUS is one of the Nucleofill range that features natural polynucleotides formulated for deeper hydration, anti-aging effects, and tissue regeneration. This advanced product targets oxidative stress and signs of aging, delivering significant improvements in skin elasticity and tone.

Type: Polynucleotide-based bio-stimulant gel.
Intended Use: Facial and body skin rejuvenation.
Packaging: Supplied in sterile, pre-filled syringes.

NUCLEOFILL MEDIUM PLUS Key Features and Benefits on Skin
This product offers comprehensive skin enhancement through hydration, regeneration, and protection while helping to stimulate collagen.

Hydration: Deep and prolonged water-binding capability enhances skin moisture levels, improving the appearance of fine lines.
Antioxidant Properties: Neutralizes free radicals, reducing oxidative stress for a refreshed skin view.
Fibroblast Stimulation: Increases collagen and elastin production for improved dermal structure.
Regenerative Action: Promotes cellular renewal and tissue repair.
Elasticity Restoration: Provides a subtle lifting effect by activating myofibroblasts.

NUCLEOFILL MEDIUM PLUS Composition
NUCLEOFILL MEDIUM PLUS, a strong Nucleofill, uses high-purity ingredients optimized for maximum efficacy.

Polynucleotide Concentration: 2.5%.
Molecular Weight: 2,500 kDa for effective dermal bioavailability.
Viscosity: 48–65 Pa*s, ensuring precise application and integration into tissues.

NUCLEOFILL MEDIUM PLUS Intended Purpose / Indications
This medicine Nucleofill is suitable for a wide range of skin rejuvenation applications.

Indications:

Severe wrinkles and sagging skin.
Skin damaged by oxidative stress.
Atrophic scars, including acne scars.

Targeted Treatment Areas:

Face: Cheeks, nasolabial folds, and jawline.
Body: Décolleté, neck, and hands.

NUCLEOFILL MEDIUM PLUS Injection and Treatment Areas
This product Nucleofill is formulated for deep and targeted rejuvenation, suitable for various treatment zones. NUCLEOFILL MEDIUM PLUS is injected in up to ten strategic points across the face.

Recommended Injection Areas:

Facial zones like periorbital regions and jawline.
Neck and chest for elasticity improvements.
Hands for volume and texture restoration.

Injection Depth: Delivered into the dermis or subcutaneous layers, depending on the treatment objective.

NUCLEOFILL MEDIUM PLUS Reconstitution and Preparation Guidelines
The product comes pre-filled and requires no additional preparation, ensuring convenience and sterility.

Preparation Guidelines:

Open the sterile packaging in an aseptic environment.
Attach the included 30G needle securely to the syringe.
Inspect the solution to ensure no particulates are present before injection.

NUCLEOFILL MEDIUM PLUS Administration and Dosage
Proper administration is crucial for achieving optimal results while minimizing risks.

Injection Techniques:

Use multi-puncture or linear threading methods based on the area.
Deliver approximately 0.1 mL per point at intervals of 1 cm.

Dosage:

A typical session requires 1.5 mL per area, depending on the extent of treatment.
Initial treatments involve 3 sessions spaced 15–30 days apart.

NUCLEOFILL MEDIUM PLUS Storage Instructions
After patients buy Nucleofill dermal filler, proper storage of the product ensures its efficacy and safety.

Store at 2–30°C in a dry, light-protected environment.
Avoid freezing and ensure the package remains sealed until use.
Always verify the expiration date before administration.

NUCLEOFILL MEDIUM PLUS Contraindications
Specific conditions must be considered to avoid adverse effects.

Not Suitable For:

Patients allergic to polynucleotides or related components.
Areas with active infections or inflammation.
Pregnant or breastfeeding individuals.
Patients with autoimmune disorders or severe chronic illnesses.

NUCLEOFILL MEDIUM PLUS Precautions and Warnings
Strict adherence to safety precautions ensures successful business and personal outcomes.

Avoid injecting near blood vessels to minimize risks of intravascular complications.
Do not mix with other injectables or undergo simultaneous aesthetic procedures.
Thorough patient consultation is necessary to assess suitability and risks.

NUCLEOFILL MEDIUM PLUS Post-Treatment Care
Post-treatment guidelines in using Nucleofill treatments such as the Nucleofill eyes promote optimal healing and results.

Care Instructions:

Avoid UV exposure, extreme temperatures, and physical exertion for 48 hours.
Use soothing, non-comedogenic skincare products.
Apply SPF 50 sunscreen daily to protect treated areas.

NUCLEOFILL MEDIUM PLUS Side Effects and Adverse Reactions
The product is well-tolerated, with minimal side effects reported.

Common Side Effects:

Redness, mild swelling, and tenderness at injection sites.
Temporary bruising or itching.

Rare Reactions:

Formation of small nodules or discoloration that resolve with time.

NUCLEOFILL MEDIUM PLUS Patient Eligibility
This product is suitable for adults looking to bring back youthful skin while benefiting from comprehensive skin rejuvenation supplies.

Ideal Candidates:

Adults with moderate to severe skin aging or oxidative damage.
Those seeking non-invasive solutions for volume and elasticity improvement.

Not recommended for individuals under 18 years or with unrealistic expectations.

NUCLEOFILL MEDIUM PLUS Follow-Up and Maintenance
A consistent treatment protocol ensures sustained and enhanced results.

Follow-Up Schedule:

Initial treatment series of 3 sessions every 2–4 weeks.
Maintenance sessions every 4–6 months, depending on patient needs.

NUCLEOFILL MEDIUM PLUS Manufacturer and Regulatory Information
NUCLEOFILL MEDIUM PLUS is produced by Biosimil Aesthetics, a leader in polynucleotide-based solutions, and is frequently used in medical spa treatments. Its regulatory status remains ongoing in 2024 as it undergoes evaluation to meet the FDA’s new safety standards under the Modernization of Cosmetics Regulation Act of 2022.

Manufacturer: Biosimil Aesthetics.
Certifications: CE-marked for safety and efficacy in skin rejuvenation.