PLINEST® EYE (1 x 2ml), PN-HPT™ Periorbital Polynucleotide Booster
The periorbital specialist. Clinically proven results for the most delicate skin on the face.
The eye contour is one of the first areas to show visible signs of ageing, and one of the most difficult to treat. Thin, highly mobile skin, minimal subcutaneous fat, and constant mechanical movement from blinking and expression make it uniquely vulnerable to fine lines, crow’s feet, laxity, and a persistently tired appearance. Standard skin boosters are often too viscous, too stimulating, or simply not formulated for use this close to the eye.
PLINEST® EYE is Mastelli’s dedicated periorbital polynucleotide treatment, the same PN-HPT™ technology as the rest of the Plinest range, but specifically developed and clinically validated for the eye contour. In a real-world clinical survey, over 90% of patients experienced measurable improvement in fine, superficial wrinkles and overall skin appearance, results confirmed by objective 3D skin analysis using ANTERA 3D.
What PLINEST® EYE Treats
Patients most commonly request periorbital treatment to look more refreshed, less tired, and to address:
Crow’s feet, fine dynamic lines at the outer corners of the eyes
Periocular fine lines, superficial wrinkles around the upper and lower eyelid
Skin laxity and sagging, tightening of drooping eyelid tissue and loss of firmness in the periorbital zone
Dull, dehydrated periorbital skin, restoring radiance and freshness to the eye contour
Eyebrow ptosis, mild drooping of the brow associated with loss of skin tightness
Under-eye skin quality, improving texture, tone and turgidity in the lower periorbital area
Clinical data confirms tightening of periocular skin was visibly improved, including the most severely sagging areas, following a structured course of Plinest Eye treatment.
Why the Eye Contour Needs Its Own Formulation
The 15mg/2ml PN-HPT™ concentration in Plinest Eye is not a coincidence, it is the clinically validated concentration for periorbital use. Lower viscosity and a refined purification process minimise:
Oedema risk, critical in a zone prone to post-injection swelling
Inflammatory response, the periorbital area is highly reactive; over-stimulation causes prolonged downtime
Nodule or lump formation, low molecular weight ensures smooth, even distribution in thin tissue
This is why Mastelli’s own clinical consensus recommends the 15mg/2ml concentration specifically for sensitive facial skin and delicate areas including the periorbital zone.
Mechanism of Action
Injected intradermally into the periocular skin, PN-HPT™ activates the skin’s regenerative cascade:
Fibroblast stimulation, triggers collagen and elastin synthesis, progressively improving firmness and reducing visible fine lines
Enhanced microcirculation, improves local blood flow, reducing the tired, grey appearance common in the periorbital zone
Antioxidant protection, neutralises free radical damage, one of the primary drivers of periorbital skin ageing
Tissue hydration, highly hydrophilic PN-HPT™ acts as a volume enhancer at the cellular level, improving skin turgidity and plumpness
Administration Protocol
Parameter Detail
Injection technique Micro-droplet (spaced 0.5–1cm apart) or linear retrograde
Injection depth Intradermal
Volume per session 1–2ml
Needle gauge 30G ½” (2 x 30G ½” needles included)
Session frequency Every 14 or 21 days
Number of sessions 3–4 sessions for a full course
Maintenance Every 2–3 months to sustain results
Session duration 20–30 minutes
Downtime Minimal, mild redness/swelling typically resolves within hours
Key Product Details
Specification Detail
Active Ingredient PN-HPT™ (Polynucleotides Highly Purified Technology)
Concentration 15mg/2ml
Volume 2ml prefilled syringe
Pack Contents 1 x 2ml syringe + 2 x 30G ½” needles
Injection Area Periorbital (eye contour)
Manufacturer Mastelli Srl, Italy
Certification CE-marked medical device
Results Duration 4–6 months (maintenance every 2–3 months)
⚠️ For use by qualified and trained aesthetic practitioners only.
Why Practitioners Choose PLINEST® EYE
✅ Purpose-built for the periorbital zone, not a repurposed general skin booster; clinically developed and validated specifically for eye contour use
✅ Over 90% patient improvement rate, reduction of fine, superficial wrinkles confirmed by both clinical assessment and objective 3D skin analysis
✅ Minimised oedema and inflammatory risk, the 15mg/2ml concentration is the clinically proven safe dose for this sensitive area
✅ Tightening of sagging eyelid tissue, clinical evidence confirms visible improvement even in more severely lax periorbital areas
✅ Synergistic with other treatments, enhances outcomes when combined with laser, radiofrequency, fillers, peeling, microneedling, or surgery through the PN-HPT™ Priming effect
✅ Hormone-free and biocompatible, no hormonal additives; naturally biodegradable and well tolerated
Important Safety Information
Contraindicated in patients with known allergy to fish or fish products, bleeding disorders, autoimmune conditions affecting skin healing, active skin infection at the treatment site, or who are pregnant or breastfeeding. Common side effects include transient redness, mild swelling, and pinpoint bruising, typically resolving within hours.
Order PLINEST® EYE (1x2ml) at AlphaBotox with free shipping on orders over €350. New customer? Get 15% off your first order, automatically applied at checkout.
