EUFLEXXA®

What is EUFLEXXA®?
EUFLEXXA® is used to relieve knee pain due to osteoarthritis. It helps patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics. This product is injected into the knee and contains sodium hyaluronate. Ferring Pharmaceuticals Inc. manufactures this product.
What are the features of EUFLEXXA injection?

Prefilled syringe: This product’s prefilled syringe can prevent errors in dosing.
Non-animal origin: This product’s hyaluronic acid is of non-animal origin, which makes it safer for patients with known hypersensitivities.

What accessories/items come with EUFLEXXA®?

Three 2.25ml EUFLEXXA syringe pre-filled with 2ml sodium hyaluronate
Package insert

How does the EUFLEXXA intra-articular syringe work?
Osteoarthritis is a condition that involves the wearing down of cartilage. In knee osteoarthritis, there may not be enough or a decrease in the quality of hyaluronan in the joint and surrounding tissues. Hyaluronan is a natural substance found in the body. It is present in exceptionally high amounts in joint tissues and the fluid that fills the joints. The body’s hyaluronan acts like a lubricant and a shock absorber in the joint. It is needed for the joint to function correctly.
EUFLEXXA injections contain gel-like, elastic, sterile products containing natural, highly purified hyaluronan. This sodium hyaluronate injection can relieve chronic symptoms like pain and swelling due to knee osteoarthritis. This symptomatic relief allows patients to move freely without pain and limitation, improving their quality of life.
What are the ingredients of EUFLEXXA injections?

Sodium hyaluronate (10mg/ml)
Sodium chloride (8.5mg/ml)
Disodium hydrogen phosphate dodecahydrate (0.56mg/ml)
Sodium dihydrogen phosphate dihydrate (0.05mg/ml)
Water for injection q.s.

How long do the results last?
This intra-articular syringe must be injected directly into the affected area for optimal outcomes. Most patients notice immediate relief after their joint injections. However, patients can feel the peak effectiveness of this three-injection therapy at the end of the treatment. Moreover, the effects of EUFLEXXA injection are expected to last up to six months.
Can elderly and patients with comorbidities take EUFLEXXA?
These individuals may require a more patient-centric approach during EUFLEXXA’s three-injection therapy. Medical professionals must thoroughly understand the unique needs of these special populations to determine the appropriate Euflexxa dosage.
Moreover, you can adjust the dosage based on the patient’s severity of condition, overall health, medical history, and other factors that may influence the product’s efficacy and safety. Continuous monitoring of their health conditions and the body’s treatment response is necessary to avoid further complications, such as pain, swelling, or other adverse reactions.
What are the common EUFLEXXA injections side effects?
Similar to other treatment options, patients may experience potential side effects after taking EUFLEXXA therapy. These side effects generally range from mild to moderate and do not require medical attention.

Pain at the Injection Site: Patients may frequently experience pain or discomfort at the injection site, which usually subsides after a few days or weeks as the medication settles in the body.
Swelling and Inflammation: Some patients may experience swelling and inflammation around the knee joint after receiving Euflexxa injections. This natural response to the injections is part of the healing process.
Redness around the Knee Joint: Redness around the knee joint is usually a sign of inflammation and should subside over time. This common side effect may occur in some patients following EUFLEXXA® treatment.
Joint Effusion or Fluid Buildup in the Knee: This side effect of EUFLEXXA® can cause the knee to feel tight or swollen. Although it may be temporary, it can still result in slight discomfort.

What is the expected recovery time for my patients?
This injection procedure does not have a required recovery period. Due to its minimally invasive treatment, it only requires a quick visit to the clinic or an appointment with a doctor for administration without necessary downtime. Patients can quickly return to their daily routine.
However, it’s essential to understand these important safety tips:

Do not use it on patients with a known history of hypersensitivity to any components.
A licensed medical practitioner or doctor should administer this product.
Practice an aseptic technique when administering this product to minimize the risk of infection.
Adhere to the product’s prescribing information to ensure patient safety and care.